Abbreviation: PRDM9
Target Synonym: PFM6; KMT8B; MSBP3; ZNF899; MEISETZ
Conjugation: Unconjugated
UNIProt ID: Q9NQV7
Background: The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human PRDM9
Dilution: WB 1:500-1:2000
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