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Encompassing Amino Acids: 2-167
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Assay Conditions: Assay conditions: enzyme was incubated in 50 mM Tris pH 7.4, 150 mM NaCl, 5 mM DTT, and 12.5 mM PNPP as a substrate for 2 hours at 37°C. Absorbance was read by Tecan spectraphotometer at 405 nm wavelength.
Background: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.
Description: Human PRL 2 (GenBank Accession No. NM_080391), a.a. 2-167 with N-terminal His-tag, MW = 19.1 kDa, expressed in an E. coli expression system.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2mM KCl, 20% glycerol, and 3 mM DTT.
Genbank: NM_080391
Storage Stability: >12 months at -80°C
Tags: N-terminal His-tag
Uniprot: Q12974
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Dumaual C.M. et al., J. Histochem. Cytochem. 54 (12), 1401-1412 (2006).
2. Radke I. et al., Br. J. Cancer 95 (3), 347-354 (2006).
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