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Encompassing Amino Acids: 2-692(end)
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Background: Three types of arginine methylation exist in mammalian cells: monomethylarginine (MMA), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). Type I PRMTs ((CARM1, PRMT1, PRMT2, PRMT3, PRMT6, and PRMT8) catalyze ADMA, while type II PRMTs (e.g. PRMTs 5 and 7) catalyze SDMA. Type II PRMTs are found to be strongly implicated in diseases like cancer. For example, PRMT5 plays a role in the repression of certain tumor suppressor genes such as RB tumor suppressors while PRMT7 overexpression is observed in breast cancer
Description: Human PRMT7 (protein arginine methyltransferase 7), GenBank Accession No. NM_019023, a.a. 2-692(end) with N-terminal FLAG-tag, MW=80 kDa, expressed in Sf9 cells using a Baculovirus expression system.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 µg/ml FLAG peptide, 3 mM DTT, 20% glycerol
Genbank: NM_019023,
Host Cell Line: Sf9 cells
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal FLAG-tag
Uniprot: Q9NVM4
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Miranda, T.B., et al. J. Biol. Chem. 2004 May 28,279(22):22902-7
2. Lee, J.H., et al. J. Biol. Chem. 2005 Feb 4,280(5):3656-64.
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