Product Description: PROTAC BRD4 Degrader-12 (compound 9c) is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-12 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.39 nM and 0.24 nM, respectively[1].
Applications: Cancer-programmed cell death
Formula: C62H77F2N9O12S4
References: [1]Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.
CAS Number: 2417370-90-0
Molecular Weight: 1306.58
Compound Purity: 99.85
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Epigenetic Reader Domain;PROTAC-Linker Conjugates for PAC;PROTACs