PROTAC BRD4 Degrader-9, CAS 2417370-42-2

Product Description: PROTAC BRD4 Degrader-9 (compound 8a) is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-9 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.86 nM and 7.6 nM, respectively[1].

Applications: Cancer-programmed cell death

Formula: C59H71F2N9O15S4

References: [1]Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.

CAS Number: 2417370-42-2

Molecular Weight: 1312.50

Compound Purity: 98.23

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Epigenetic Reader Domain;PROTACs

• SKU: MEXHY-138632-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-138632-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK