Clone Name: FOLH1/3149R
Application Note: IHC-P: 1-2 μg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 84
Form: Liquid
Buffer (with preservative): 10mM PBS, 0.05% BSA, 0.05% Sodium azide.
Concentration: 200 μg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
Uniprot ID: Q04609
Antigen Species: Human
Immunogen: Recombinant human FOLH1 protein fragment (around aa 232-433)
Purification: Protein A/G purified
Conjugation: Unconjugated
Full Name: folate hydrolase 1
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