Formulation: A crystalline solid
Formal Name: (1,3-diethyl-4,5-bis(4-fluorophenyl)-1,3-dihydro-2H-imidazol-2-ylidene)(1-pyridyl)platinum(V) iodide
Purity: ≥95%
Formula Markup: C24H23F2I2N3Pt
Formula Weight: 840,3
Shelf life (days): 730
Notes: Pt(II)-NHC complex 2C is an inducer of immunogenic cell death (ICD) in cancer cells.{67009} It selectively inhibits proliferation of HT-29, MCF-7, A2780, A549, HepG2, and Hepa 1-6 cancer cells (IC50s = 2.78, 0.71, 0.99, 1.77, 0.33, and 0.36 µM, respectively) over non-cancerous L-02 liver cells (IC50 = 3.02 µM). It induces the release of damage-associated molecular patterns (DAMPs) associated with ICD in Hepa 1-6 cells by increasing calreticulin (CRT) exposure on the cell membrane, extracellular ATP release, and high mobility group protein B1 (HMGB1) translocation to the cytoplasm. Pt(II)-NHC complex 2C (2 µM) also increases the generation of reactive oxygen species (ROS), as well as induces DNA damage and cell cycle arrest at the S phase in HepG2 cells. It reduces tumor growth in a mouse antitumor vaccination model of the ICD response in mice when used at a concentration of 5 µM in Hepa 1-6 cells prior to implantation.
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