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Encompassing Amino Acids: 883-end
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Assay Conditions: 20 mM HEPES, pH 7.2, 2 mM EDTA, 1 mM DTT, 25 mM pNPP. Assay was done at room temperature for 16 minutes, and monitored continuously at Abs405 nM. ε pNPP = 18,000 M-1cm-1.
Background: PTPRS is a member of a subfamily of receptor type PTPases that is characterized by the presence of an extracellular cell adhesion molecule-like motif and 2 intracellular phosphatase domains. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis.
Description: Human PTPRS (GenBank Accession No. BC104812), a.a. 883-end, with N-terminal GST-tag, MW= 98 kDa, expressed in an E. coli expression system.
Format: Aqueous buffer solution
Formulation: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 20% glycerol, and 3 mM DTT.
Genbank: BC104812
Storage Stability: >12 months at -80°C
Tags: N-terminal GST-tag
Uniprot: Q13332
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Forrest, A.R. et al., Genome Biol. 2006;7(1):R5.
2. Muise, A. and Rotin, D. Expert Rev Mol. Diagn. 2008 Jul;8(4):465-77.
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