Pyr3, CAS 1160514-60-2

TRPC3 Channel blocker

Product Type: Inhibitor

CAS No.: 1160514-60-2

MolecularFormula: C16H11Cl3F3N3O3

Molecular Weight: 456,63

Source: Synthetic

Purity: >98%

Solubility: Soluble to 100 mM in DMSO

Appearance: White Solid

PubChem CID: 56964346

Scientific Background: Pyr3, a novel pyrazole, selectively inhibits TRPC3 channels. In B lymphocytes, Pyr3 eliminated the B cell receptor-induced Ca2+ oscillation regulated by TRPC3-mediated Ca2+ influx. In the cardiac system, Pyr3 attenuates activation of nuclear factor of activated T cells and hypertrophic growth in myocytes and pressure overloaded-induced hypertrophy in vivo (1).

References: 1. Kiyonaka S., Kato K., Nishida M., and Mori Y. (2010) Yakugaku Zasshi. 130(3): 303-311.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• SKU: STRSIH-306-10MG
• Manufacturer: Stressmarq Biosciences
• Manufacturer SKU: SIH-306-10MG
• Package Unit: 10 mg
• Quantity Unit: STK