Product Description: QC-01-175 is a heterobifunctional molecule, which degrades aberrant tau. QC-01-175 reduces the levels of A152T and P301L mutant tau protein and protects neurons from tau-mediated toxicity and improve cell survival (Pink: ligand for target protein Aberrant tau ligand 1 (HY-W453397); Black: linker NH2-PEG3 (HY-W007545); Blue: ligand for E3 ligase Pomalidomide (HY-10984))[1][2].
Applications: Neuroscience-Neurodegeneration
Formula: C33H34N6O7
References: [1]Silva MC, et al., Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. Elife. 2019 Mar 25;8:e45457./[2]Tiziana Petrozziello, et al. Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis. Mol Neurobiol. 2022 Jan;59(1):683-702.
CAS Number: 2267290-96-8
Molecular Weight: 626.66
Compound Purity: 99.94
Research Area: Neurological Disease
Solubility: DMSO : 125 mg/mL (ultrasonic)
Target: PROTACs;Tau Protein
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