Formulation: A crystalline solid
Formal Name: 6'-methoxy-cinchonan-9S-ol
Purity: ≥95% (may contain up to 15% hydroquinidine)
Formula Markup: C20H24N2O2
Formula Weight: 324,4
Shelf life (days): 1460
CAS Number: 56-54-2
Notes: Quinidine is a stereoisomer of the antimalarial agent quinine (Item No. 23958) and a class Ia antiarrhythmic agent.{37790,37791} Quinidine blocks the voltage-gated sodium (Nav) channel Nav1.5 in a use-dependent manner.{37790} It decreases the amplitude and duration of action potentials in isolated canine ventricular myocytes.{37792} It inhibits KKr, peak INa, and late INa (IC50s = 4.5, 11, and 12 µM, respectively) and can induce torsade de pointes in isolated rabbit hearts when used at a concentration of 1 µM.{37791} Quinidine induces QT prolongation in dogs.{37793} It also binds to M2 muscarinic acetylcholine receptors (Ki = 7.5 µM for human recombinant receptors expressed in HM2-B10 cells).{37794} Formulations containing quinidine have been used in the treatment of atrial fibrillation and ventricular arrhythmias.
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