R(-)-Gossypol, CAS 303-45-7

Bcl-2 inhibitor

Product Type: Inducer

CAS No.: 303-45-7

MolecularFormula: C30H30O8

Molecular Weight: 518,56

Source: Synthetic

Purity: >98%

Solubility: Soluble to 25 mM in ethanol and in DMSO.

Appearance: Dark Yellow Solid

PubChem CID: 3503

Scientific Background: Gossypol is a natural phenol derived from the cotton plant, and is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. It has proapoptotic properties, due to the regulation of the Bax and Bcl2. It also reversibly inhibits calcineurin and binds to calmodulin (1, 2).

References: 1. www.bioscreening.net “Gossypol”2. Carruthers N.J., Dowd M.K., and Stemmer P.M. (2007) Eur J Pharmacol. 555(2-3): 106-114.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• SKU: STRSIH-223-50MG
• Manufacturer: Stressmarq Biosciences
• Manufacturer SKU: SIH-223-50MG
• Package Unit: 50 mg
• Quantity Unit: STK