Clone Number: EP120
Immunogen: A synthetic peptide corresponding to residues in the N-terminus of human Androgen Receptor protein
Concentration: n/a
Storage buffer: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Additional info: Androgen receptor (AR) is a member of the steroid receptor superfamily that is essential for the growth of prostate cancer cells. Ithas been reported that tyrosine phosphorylation of AR is induced by growth factors and elevated in hormone-refractory prostate tumors. Data suggest that growth factors and their downstream tyrosinekinases, which are elevated during hormone-ablation therapy, can induce tyrosine phosphorylation of AR. Such modification may be important for prostate tumor growth under androgen-depletedconditions. Cellular signaling occurs following androgen binding tothe AR and translocation to the nucleus. This activated complex associates with androgen-responsive elements contained in the DNAsequence of target genes, affecting the transcriptional activity of these genes.
References: Horie K, et al.Hum Reprod, 1992, 7:1461-1466/Loda M, et al.: Mod Pathol, 1994, 7:388-391/Miyamoto H, et al.: Prostate, 2004, 61:332-353
English
Deutsch
