Clone Number: SP91
Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers
Concentration: n/a
Storage buffer: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Additional info: Acute humoral rejection is mediated by antibodies to the donor endothelium that activate the classical complement pathway. This leads to a number of split products of complement proteins. C4d is a fragment of C 4 complement released during activation of the classic complement pathway by the antigen antibody complex. C4d deposits in peritubular capillaries and is regarded as an indirect sign of an antibody response. C4d can be a useful tool for indicating acute renal allograft rejection
References: Jianghua C, et al. Clin Transplant. 2005; 19:785-91/Kayler LK, et al. Transplantation. 2008; 85:813-20/Ranjan P, et al. Nephrol Dial Transplant .2008; 23:1735-41
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