Background: Sphingomyelin synthases are enzymes that mediate the biosynthesis of sphingolipid headgroups. Sphingomyelin synthase 1 and 2 (SMS1 and SMS2) mediate the biosynthesis of sphingomyelin, a central sphingolipid in mammalian cells. In addition to SMS1 and SMS2, a third SMS-related protein, SMSr, is known, however its function remains largely unknown. SMSr also occurs in organisms which lack sphingomyelin, such as the fruit fly Drosophila melanogaster. Its function appears to be biosynthesis of ethanolamine phosphorylceramide (EPC), a sphingolipid structurally related to sphingomyelin. SMSr has also been found in mammals as well.
Positive Control: Recombinant sphingomelin synthase protein.
Immunogen: Recombinant SMSr derived from Drosophila .
Purification Method: Ammonium Sulfate Precipitation.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
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UniProt: Q9VS60.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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