Background: APM2 is an ~8kDa protein which for some time was found only in the EST data base but never as an expressed protein. APM2 has since been shown to be associated with cisplatin resistance in cell lines. APM2 is not found in cisplatin sensitive cell lines. These data implicate APM2 in the development of cisplatin resistance in tumor cells.
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Positive Control: Adipose tissue, cornea and liver.
Purification Method: Ammonium Sulfate Precipitation.
Source: Rabbits were immunized with a synthetic peptide derived from human APM2 protein.
References: 1. Scott, B.J., et al. APM2 is a novel mediator of cisplatin resistance in a variety of cancer cell types regardless of p53 or MMR status. Int. J. Cancer 2009, 125, 1193-1204.
UniProt: Q15847.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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