Background: Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-ctx-GVIA) and omega-agatoxin-IVA (omega-aga-IVA).
Positive Control: Rat brain lysate.
Immunogen: Synthetic peptide derived from the rat beta1 calcium channel conjugated to KLH.
Purification Method: Ammonium Sulfate Precipitation.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Powers, P.A., et al. 'Skeletal muscle and brain isoforms of a beta-subunit of human voltage-dependent calcium channels are encoded by a single gene.' J. Biol. Chem. 1992, 267, 22967-22972.
2. Collin, T., et al. 'Molecular cloning of three isoforms of the L-type voltage-dependent calcium channel beta subunit form normal human heart.' Circ. Res. 1993, 72, 1337-1344.
3. Fukuda, K., et al. 'Cyclic AMP-dependent modulation of N- and Q-type Ca2+ channels expressed in Xenopus oocytes.' Neurosci. Lett. 1996, 217, 13-16.
4. Hogan, K., et al. 'Structure and alternative splicing of the gene encoding the human beta1 subunit of voltage dependent calcium channels.' Neurosci. Lett. 1999, 277, 111-114.
UniProt: Q02641.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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