Background: Heterologous expression studies have shown that the activity of voltage-gated Ca2+ channels is regulated by their beta subunits in a beta subunit isoform-specific manner. Our data show that all four beta subunit isoforms associate with L-type Ca2+ channels in mammalian brain. This beta subunit heterogeneity may play an important role for the fine tuning of L-type channel function and modulation in neurons.
Positive Control: Rat brain lysate
Purification Method: Ammonium Sulfate Precipitation
Concentration: See vial for concentration
Source: Rabbits were immunized with a synthetic peptide derived from the rat beta2 calcium channel conjugated to KLH.
References: 1. Perez-Reyes,Eet.al 'Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel.' J. Biol. Chem. 1992, 267, 1792-1797
UniProt: Q5VVH1
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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