Background: Heterologous expression studies have shown that the activity of voltage-gated Ca2+ channels is regulated by their beta subunits in a beta subunit isoform-specific manner. Our data show that all four beta subunit isoforms associate with L-type Ca2+ channels in mammalian brain. This beta subunit heterogeneity may play an important role for the fine tuning of L-type channel function and modulation in neurons.
Positive Control: Rat brain lysate.
Immunogen: Synthetic peptide derived from the rat calcium channel beta4 subunit conjugated to KLH.
Purification Method: Ammonium Sulfate Precipitation.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Castellano,A et.al 'Cloning and expression of a neuronal calcium channel beta subunit' J. Biol. Chem. 1993, 268 (17), 12359-12366.
UniProt: O00305.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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