Background: Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1c gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-ctx-GVIA) and omega-agatoxin-IVA (omega-aga-IVA). Calcium channels containing the alpha-1c subunit play an important role in excitation-contraction coupling in the heart.
Positive Control: Normal human kidney tissue.
Immunogen: Synthetic peptide derived from the rat alpha1C calcium channel conjugated to KLH.
Purification Method: Antigen Immunoaffiinity Purification.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Snutch,T.P et.al 'Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian' CNS Neuron 7 (1), 45-57 (1991)
2. Hansen, P.B. et.al 'Differential expression of T- and L-type voltage-dependent calcium channels in renal resistance vessels.' Circ Res;89(7):630-8 (2001)
3. Chung,Y.H. et.al 'Differential alterations in the distribution of voltage-gated calcium channels in aged rat cerebellum.' Brain Res 8;903(1-2):247-52.(2001).
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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