Background: Ceramide Glycosyltransferase may serve as a flippase as well as a glucosyltransferase that transfers glucose to ceramide. It Catalzes; UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine. Ceramide Glycosyltransferase is the first step in the Glycosphingolipid synthesis; first glycosylation step. Glucosylceramide synthase (GlcT) and lactosylceramide synthase (GalT) are key enzymes for the synthesis of major glycosphingolipids of vertebrates.
Positive Control: Found in all tissues examined.
Purification Method: Ammonium Sulfate Precipitation.
Source: Rabbits were immunized with a synthetic peptide derived from human ceramide glycosyltransferase protein.
References: 1. Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis.; Ichikawa S., Sakiyama H., Suzuki G., Hidari K.I.-P., Hirabayashi Y.; Proc. Natl. Acad. Sci. U.S.A. 93:4638-4643(1996).
2. van Vlerken, L.E., et al. ‘Modulation of Intracellular Ceramide Using Polymeric Nanoparticles to Overcome Multidrug Resistance in Cancer.’ Cancer Res., 67, 4843-4850, (2007).
UniProt: Q16739.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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