Background: Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, and CCR2b in the chemokine receptor family have been identified as HIV coreceptors. An orphan G protein-coupled receptor was recently cloned and designated Bonzo, STRL33 and TYMSTR, and identified as an HIV and SIV coreceptor1-4. Bonzo/STRL33 is used by SIV, HIV-2 and HIV-1. The messenger RNA of Bonzo/STRL33 is expressed in lymphoid tissues and activated peripheral blood lymphocytes.
Positive Control: Human spleen tissue lysates.
Immunogen: Antibody raised against a synthetic peptide corresponding to amino acids 11 to 25 of the human Bonzo protein. Peptide sequence differs from those of African green monkey and pig-tailed macaque by one or two amino acids, respectively.
Purification Method: Antigen Immunoaffiinity Purification.
Formulation: Provided in phosphate buffered saline solution containing 0.02% sodium azide as a preservative.
References: 1. Deng, H.K., et al. 'Expression cloning of new receptors used by simian and human immunodeficiency viruses.' Nature 1997, 388, 296-300
2. Liao, F., et al. 'STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1.' J. Exp. Med. 1997, 185, 2015-2023
3. Alkhatib, G., et al. 'A new SIV co-receptor, STRL33.' Nature 1997, 388, 238
4. Loetscher, M., et al. 'TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function.' Curr. Biol. 1997, 7, 652-660.
UniProt: O00574.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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