Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
Positive Control: Widely expressed in most human tissues.
Immunogen: Synthetic peptide dervied from the human FBXW7 protein.
Purification Method: Antigen Immunoaffiinity Purification.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Strohmaier, H., et al. 'Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line.; Nature 413:316-322(2001).
2. Moberg, K.H., et al. 'Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines.; Nature 413:311-316(2001).
UniProt: Q969H0.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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