Background: GAPDH is constitutively expressed at high levels in almost all tissues and cell lines making it ideal for use as a loading control marker in immunoblots. Independent of its glycolytic activity it is also involved in membrane trafficking in the early secretory pathway.
Positive Control: Human liver tissue, human testis.
Immunogen: Synthetic peptide derived from the human GAPDH alpha protein.
Purification Method: Antigen Immunoaffiinity Purification.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Nakajima, H., et al. 'GAPDH aggregate formation participates in oxidative stress-induced cell death.' J. Biol. Chem. 2009:Epub
2. Nahlik, K.W., et al. 'Modulation of GAPDH expression and cellular localization after vaccinia virus infection of human adherent monocytes.' Acta Biochim. Pol. 2003: 50(3); 667-676.
UniProt: P04406.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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