Background: LASS2, a human homologue of the yeast longevity assurance gene LAG1 is highly expressed in liver and kidney as compared to the expression of the human LAG1 homologue LAG1Hs-1. LASS2 is located on chromosome 1q11. The LASS2 protein interacts with several membrane-associated receptors or transporters. LASS2 protein inhibits the colony formation of human hepatoma cells in vitro, which suggests that this gene may be involved in the regulation of cell growth.
Positive Control: liver and kidney.
Immunogen: Synthetic peptide derived from human Lass2 protein.
Purification Method: Ammonium Sulfate Precipitation.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1: Becker I, Wang-Eckhardt L, Yaghootfam A, Gieselmann V, Eckhardt M.Differential expression of (dihydro)ceramide synthases in mouse brain: oligodendrocyte-specific expression of CerS2/Lass2.
Histochem Cell Biol. 2008 Feb;129(2):233-41. Epub 2007 Sep 28.
2: Wang X, Carré W, Saxton AM, Cogburn LA. Manipulation of thyroid status and/or GH injection alters hepatic gene expression in the juvenile chicken.
Cytogenet Genome Res. 2007;117(1-4):174-88.
3:Senkal CE, Ponnusamy S, Rossi MJ, Bialewski J, Sinha D, Jiang JC, Jazwinski SM, Hannun YA, Ogretmen B. Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas.
Mol Cancer Ther. 2007 Feb;6(2):712-22.
4: Yu Y, Lu H, Pan H, Ma JH, Ding ZJ, Li YY. Expression of LASS2 controlled by LAG1 or ADH1 promoters cannot functionally complement Lag1p.
Microbiol Res. 2006;161(3):203-11. Epub 2005 Sep 22.
UniProt: Q96G23.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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