Background: EDG4 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG4 is lysophospholipid. There are 6 known members of the EDG receptor family and they are implicated in mediating growthrelated effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG4 is expressed in testes, ovarian tumor and leukocyte containing tissues.
Positive Control: RH7777 cells transfected with EDG4 protein.
Immunogen: Antibody raised against a unique synthetic peptide derived from the N-terminal of the human EDG4 protein. Antigen sequence differs in mouse and rat by one amino acid.
Purification Method: Ammonium Sulfate Precipitation.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Goetzl EJ and An, S. Diversity of cellular receptors and functions for the lysophospholipid growth factos lysophosphatidic acid and sphingosine 1-phosphate. FASEB J. 1998, 12, 1589-98.
2. An, S., Goetzl, E.J., Lee, H. Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate. J. Cell Biochem. Suppl. 1998, 30-31, 147-57.
3. Yun, C. Chris, et al. 'LPA2 receptor mediates mitogenic signals in human colon cancer cells.' Am. J. Physiol Cell Physiol 2005, 289, C2-C11.
UniProt: Q9HBW0.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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