Background: Endothelial Cell Differentiation Gene-7 (EDG-7) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-7 is lysophospholipid. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-7 is expressed in prostate as well as other tissues.
Positive Control: RH7777 cells transfected with EDG7 protein (Cat. No. X1220C).
Immunogen: Antibody raised against a unique synthetic peptide derived from the C-terminal of the human EDG7 protein.
Purification Method: Ammonium Sulfate Precipitation.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Bandoh, K., et al. Molecular cloning and characterization of a novel human G-protein coupled receptor, EDG7, for lysophosphatidic acid. J. Biol. Chem. 1999, 274, 27776-27785
2. Im, D.S., et al. Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. Mol. Pharmacol. 2000, 57, 753-759
3. Fang, X., et al. Lysophospholipid growth factors in the initiation, progression, metastases, and management of ovarian cancer. Ann. N.Y. Acad. Sci. 2000, 905, 188-208.
UniProt: Q9UBY5.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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