Background: Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. It catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG), and is a pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. It is a major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. It may control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. Its down-regulation may contribute to the development of colon adenocarcinoma.
Immunogen: Synthetic peptide derived from the LPP1 protein.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Roberts, RZ, Morris, AJ. 'Role of phosphatidic acid phosphatase 2a in uptake of extracellular lipid phosphate mediators.' Biochim Biophys Acta, 2000, 1487, 33-49
2. Roberts, RZ, Sciorra, VA, Morris, AJ. 'Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b and 2c enzymes and cell surface activity of the 2a isoform.' J Biol Chem, 1998, 273, 22059-22067.
UniProt: O14494(Human).
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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