Background: Monocarboxylate Transporter 3 (MCT3) is a proton-linked monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.
Positive Control: Retinal pigment epithelium.
Immunogen: Synthetic peptide derived from MCT3 protein.
Purification Method: Ammonium Sulfate Precipitation.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Yoon, H., et al. Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2.; Genomics 60:366-370(1999).
2. Zhu, S., et al. 'Inactivation of monocarboxylate transporter MCT3 by DNA methylation in atherosclerosis.' Circulation. 2005 Aug 30;112(9):1353-61.
3. Philip, N.J., et al. 'Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse.' Invest Ophthalmol Vis Sci. 2003 Mar;44(3):1305-11.
UniProt: O95907 (Human).
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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