Background: Novel methylation target specific for cervical cancer. Could be a marker in the early detection, risk prediction and etiologic research of cervial cancer. While the biological role of NOL4 in cervical cancer has yet to be determined, it is possible that it could be a potential tumor suppressor gene. It also appears to have important roles in cell cycle and apoptosis as well as functioning in ribosomal transcription and subunit assembly.
Immunogen: Synthetic peptide derived from the human NOL4 protein.
Purification Method: Ammonium Sulfate Precipitation.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Ueki, N., et al. 'NOLP: identification of a novel human nucleolar protein and determination of sequence requirements for its nucleolar localization.' Biochem Biophys Res Commun 1998;252:97-102.
2. Wang, S.S., et al. 'Identification of novel methylation markers in cervical cancer using restriction landmark genomic scanning.' Cancer Res 2008;68:2489-2497.
3. Visintin R, et al. 'The nucleolus: the magician's hat for cell cycle tricks.' Curr Opin Cell Biol 2000;12:372–7.
4. Olson MO, et al. 'The nucleolus: an old factory with unexpected capabilities.' Trends Cell Biol 2000;10:189–96.
UniProt: O94818-Human.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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