Background: OGR1 (originally identified as GPR68) is a high-affinity receptor for sphingosylphosphorylcholine (SPC). SPC is a member of a class of bioactive lipids which regulate cellular functions. These functions include cell proliferation and growth inhibition, smooth muscle contration and wound healing. SPC also stimulated signalling pathways that induce tyrosine phosphorylation, activate MAP kinases and protein kinase C, modify ion channel activity and increase intracellular Ca2+ concentration. OGR1 is expressed in placenta, lung, liver, spleen, testis, small intestine and peripheral blood leukocytes. It is not found in thymus, ovary, colon, skeletal muscle, kidney or pancreas.
Positive Control: OGR1 transfected cell lysate.
Purification Method: Protein A/G Chromatography.
Source: Rabbits were immunized with recombinant protein derived from human OGR1 (GPR68).
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Xu, Y., et al. 'Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.' Nature Cell Biol., 2, 261-267 (2000)
2. Singh, L.S., et al. ‘Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer.’ J. Natl. Cancer Inst., 99, 1313-1327 (2007)
3. Yang, M., et al. ‘Expression of and Role for Ovarian Cancer G-protein-coupled Receptor 1 (OGR1) during Osteoclastogenesis’ J. Biol. Chem., 281, 23598-23605 (2006).
UniProt: Q15743.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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