Rabbit anti Human PH domain leucine-rich repeat-containing protein phosphatase 2

Rabbit anti Human PH domain leucine-rich repeat-containing protein phosphatase 2, Polyclonal, Ig

Background: PHLPP2 is a protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.

Positive Control: Normal human kidney.

Immunogen: Synthetic peptide derived from the human PHLPP2 protein.

Purification Method: Antigen Immunoaffinity Purification.

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.

UniProt: Q6ZVD8.

Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

• SKU: EXAX2737P
• Manufacturer: Exalpha Biologicals Inc
• Manufacturer SKU: X2737P
• Green Labware: No
• Package Unit: 100 µg
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Polyclonal
• Application: Western Blotting, ELISA, Immunohistochemistry
• Isotype: Ig
• Host: Rabbit