Background: Stanniocalcin 1 is a secreted disulfide-linked homodimeric glycoprotein belonging to the stanniocalcin family of proteins. It is widely expressed and has endocrine/paracrine/autocrine functions relating to calcium and phosphate homeostasis, reproduction, and development. In the ovary, it has been shown to be a paracrine hormone that regulates granulosa cell function. It also has been known to. stimulate renal phosphate reabsorption, and could therefore prevent hypercalcemia.
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Positive Control: Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid. In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the collecting tubule. Not detected in the brain, liver, spleen, peripheral blood leukocytes,adrenal medulla.
Immunogen: Synthetic peptide derived from the human STC-1 protein.
Purification Method: Antigen Immunoaffiinity Purification.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Jeffrey K.J., Reddel R.R., 'Characterization of the human stanniocalcin 1 gene.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
2. Olsen H.S., Cepeda M.A., Zhang Q.-Q., Rosen C.A., Vozzolo B.L., Wagner G.F., Human stanniocalcin: a possible hormonal regulator of mineral metabolism.
Proc. Natl. Acad. Sci. U.S.A. 93:1792-1796(1996) [PubMed: 8700837] [Abstract].
UniProt: P52823.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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