Background: Rabbit anti-human TOB (Transducer Molecule of erbB-2) reacts with a 45 kDa protein originally identified as a molecule that interacts with the ErbB-2 protein, a receptor protein tyrosine kinase (RPTK). TOB does not contain either SH2 or SH3 domains but is homologous with the N terminus of the anti-proliferative BTG-1 protein. Like BTG-1, TOB when exogenously expressed, is able to suppress the growth of NIH3T3 cells. This growth suppression is hindered by the presence of kinase-active p185erbB2.
Positive Control: HeLa cell lysate.
Immunogen: Synthetic peptide derived from the TOB protein.
Purification Method: Ammonium Sulfate Precipitation.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Matsuda, S., et al. 'Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity.' Oncogene 1996: 12, 705-713.
UniProt: P50616.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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