Background: Zinc Finger Protein GLI1 is a member of the Kruppel family of zinc finger proteins. It is thought that it may regulate the transcription of specific genes during normal development and may play a role in craniofacial development and digital development. It also may be involved in the development of the central nervous system and gastrointestinal tract. This protein mediates SHH signaling and thus cell proliferation and differentiation. It has been localized to the cytoplasm and nucleus. It is tethered in the cytoplasm by binding to SUFU and activation and translocalization to the nucleus is promoted by interation with STK36. Protein expression is amplified in glioblastoma cells. Defects in the GLI1 protein may be a cause of breast cancer.
Positive Control: Protein found in testis, myometrium and fallopian tube.
Immunogen: Synthetic peptide derived from human zinc finger protein GLI1.
Purification Method: Antigen Immunoaffiinity Purification.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Kinzler, K.W., et al. 'The GLI gene is a member of the Kruppel family of zinc finger proteins.; Nature 332:371-374(1988).
2. Wang, Z.Q., et al. 'Identification of polymorphic variants of the GLI1 oncogene.; J. Invest. Dermatol. 115:328-329(2000).
UniProt: P08151 (Human).
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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