Rabbit anti-p16INK4a Recombinant Monoclonal Antibody (BLR318M)

Stock Concentration: 500 µg/ml

Conjugate Type: Unconjugated

Buffer: Phosphate Buffered Saline (PBS) with 0.1% BSA and 0.09% Sodium Azide

Shelf Life: 1 year from date of receipt

Protein ID: NP_000068.1

Uniprot ID: P42771

Background: p16INK4a is a negative regulator of CDK4 and CDK6 kinase activity and cell cycle progression. p16INK4a regulates the cell cycle by inhibiting cyclin/CDK complex formation and the phosphorylation of the retinoblastoma protein (pRb). The gene which encodes p16INK4a, CDKN2A, is frequently mutated or deleted in a wide variety of tumors and is known to be an important tumor suppressor gene. The CDKN2A gene also generates a distinct transcript variant and protein, p14ARF, from an alternate open reading frame (ARF).

Immunogen: Between 106 and 156 (C-term)

• SKU: BEYA700-318-T
• Manufacturer: Bethyl Laboratories
• Manufacturer SKU: A700-318-T
• Green Labware: No
• Package Unit: 10 µl (5+ tests)
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Immunoprecipitation, Western Blotting, Flow Cytometry, Immunohistochemistry, Immunocytochemistry
• Isotype: Whole IgG
• Human Gene ID: 1029
• Host: Rabbit