Background: BAPTA ((1,2-bis(2-Aminophenoxy)ethane-N,N,N',N'- tetraacetic acid) is a highly selective calcium chelator. BAPTA has spawned many of the most familiar fluorescent indicators for calcium and other ions. BAPTA and its analogs including BAPTA-AM have proven most critical in cell physiology research where they have been essential in defining the mechanisms underlying inter- or intracellular calcium homeostasis and calcium dependent exocytosis. BAPTA and its analogs may also find application in the study of diseases in which the regulation of excitatory neurotransmitter release and uptake has been disturbed.
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Immunogen: Synthetic peptide derived from the human BAPTA protein.
Purification Method: Ammonium Sulfate Precipitation.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Tymianski, M. et al. (1997) Cell Calcium 22: 111-120
2. Roberts, W. M. (1993) Nature 363: 74-76
3. Kline, D. at al. (1992) Dev. Bio. 149: 80-89
4. Choi, D.W. (1998.
UniProt: P60815.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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