Background: The calcium channel alpha2/delta subunit is a glycosylated structural subunit consisting of the alpha2 subunit and the delta peptide. There is distinctive alpha2 subunit expression in rat spinal cord and dorsal root ganglia (DRG) There are two forms of the alpha2 subunit in DRG that are different from the alpha2 subunit in other tissues examined, at least at the glycosylation level. Thus, post-translational modification may be important in tissue specific and functional expression of the alpha2/delta subunit (2). alpha2/delta and beta1b interact with alpha1G to increase trafficking of, or stabilize, functional alpha1G channels expressed at the plasma membrane.(3)
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Positive Control: Rat brain lysate.
Immunogen: Synthetic peptide derived from the rat alpha2/delta calcium channel conjugated to KLH.
Purification Method: Ammonium Sulfate Precipitation.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Kim, H.L et.al. 'Rat brain expresses an alternatively spliced form of the dihydropyridine-sensitive L-type calcium channel alpha 2 subunit.' Proc. Natl. Acad. Sci. U.S.A. 89 (8), 3251-3255 (1992)
2. Luo, Z.D. 'Rat dorsal root ganglia express distinctive forms of the alpha2 calcium channel subunit.' Neuroreport.;11(16):3449-52 (2000)
3. Dolphin, AC et al. 'The effect of alpha2-delta and other accessory subunits on expression and properties of the calcium channel alpha1G.' J Physiol.;519 Pt 1:35-45.(1999).
UniProt: Q8VHS9.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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