Background: Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1a gives rise to p and/or q-type calcium currents. P/q-type calcium channels belong to the 'high-voltage activated' (hva) group and are blocked by the funnel toxin (ftx) and by the omega-agatoxin-IVA (omega-aga-IVA). They are however insensitive to dihydropyridines (dhp), and omega- conotoxin-GVIA (omega-ctx-GVIA). voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.
Positive Control: Rat brain lysate, human brain tissue
Immunogen: Synthetic peptide derived from the rat 1A calcium channel conjugated to KLH
Purification Method: Antigen Immunoaffiinity Purification
Concentration: Lot specific, see vial
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide
References: 1. Starr,T.V.B et.al 'Primary structure of a calcium channel that is highly expressed in the rat cerebellum' Proc. Natl. Acad. Sci. U.S.A. 88, 5621-5625 (1991) 2. Snutch,T.Pet.al 'Rat brain expresses a heterogeneous family of calcium channels' Proc. Natl. Acad. Sci. U.S.A. 87 (9), 3391-3395 (1990)3. Yu,A.S et.al. 'Molecular characterization and nephron distribution of a family of transcripts encoding the pore-forming subunit of Ca2+ channels in the kidney' Proc. Natl. Acad. Sci. U.S.A. 89 (21), 10494-10498 (1992)4. Hansen PB, , et al.'Vascular smooth muscle cells express the alpha(1A) subunit of a P-/Q-type voltage-dependent Ca(2+)Channel, and It is functionally important in renal afferent arterioles.' Circ Res (United States) 87(10) p896-902 (2000)5. Stephens,G.I. et.al 'The Cav2.1/alpha1A (P/Q-type) voltage-dependent calcium channel mediates inhibitory neurotransmission onto mouse cerebellar Purkinje cells.' Eur J Neurosci 13(10) 1902-12 (2001)
UniProt: P54282 (Rat)
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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