Background: The Kv1.4 potassium channel is a voltage-gated channel protein which belongs to the delayed rectifier class and to the Shaker potassium channel subfamily which includes Kv1.1, Kv1.2, Kv1.3 and Kv1.5. Potassium channels are mainly found in plasma membranes but are not generally distributed over the cell surface. Potassium channels catalyze the rapid permeation of potassium ions while rejecting biologically abundant potential competitors such as sodium, calcium and magnesium. Ion selectivity and high through put rate of potassium channels is accomplished by precise co-ordination of dehydrated potassium by the protein and multiple ion occupancy within the permeation pathway. All potassium channels carry out the formation of a transmembrane leak specific for potassium ions. Since cells almost universally maintain cytoplasmic potassium concentrations higher than those extracellularly, the opening of a potassium channel implies a negative ongoing change in electrical voltage across the cell membrane. This may result in termination of the action potential of electrically excitable cells including nerve, muscle and pancreatic beta cells. In nonÐexcitable cells, potassium channels play important roles in the cellular potassium recycling required for electrolyte balance effected by the renal epithelium.
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Immunogen: Synthetic peptide derived from the N-terminus of the rat Kv1.4 potassium channel conjugated to KLH.
Purification Method: Ammonium Sulfate Precipitation.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Matsubara, H., et al. 'Shaker-related potassium channel, Kv1.4, mRNA regulation in cultured rat heart monocytes and differential expression of Kv1.4 and Kv1.5 genes in myocardial development and hypertrophy.' J. Clin. Invest. 1993, 92 1659-1666
2. Rasmusson, R.L., et al. 'C-type inactivation control recovery in a fast inactivating cardiac K+ channel (Kv1.4) expressed in Xenopus oocytes.' J. Physiol. 1995, 489, 709-721
3. Guo, W., et al. 'Regulation of Kv4.2 and Kv1.4 K+ channel expression by myocardial hypertrophic factors in cultured newborn rat ventricular cells.' J. Mol. Cell. Cardiol. 1998, 30, 1449-1455
4. Chanda, B., et al. 'Transplanting the N-terminus from Kv1.4 to Kv1.1 generates an inwardly rectifying K+ channel.' Neuroreport 1999, 10, 237-241.
UniProt: P22459.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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