Clone Number: EP325
Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers
Concentration: n/a
Storage buffer: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Additional info: STAT6, a member of the signal transducers and activators of transcription (STAT) family, has been found to form recurrent fusions with NAB2 on chromosome 12q13 in the majority of solitary fibrous tumors.1- 3 Inactivated STAT6 can be found in the form of a dimer located in the cytoplasm. STAT6 and NAB2 fusion enables cytosolic STAT6 to migrate to the nucleus and thus allowing for detection in immunohistochemical assays. NAB2-STAT6 fusion transcriptions have been reported in the majority of solitary fibrous tumors but not in meningiomas, hemangioblastomas, schwannomas, and hemangiomas. This makes STAT6 a useful marker in distinguishing solitary fibrous tumors from other morphologically similar tumors.
References: Cheah AL, et al. Pathology. 2014; 46:389-95/Schweizer L, et al. Acta Neuropathol. 2013; 125:651-58/Koelsche C, et al. Histopathology. 2014; 65:613-22
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