Notes: Rabeprazole sulfide is an active metabolite of the proton pump inhibitor rabeprazole (Item No. 14939).{62901} It inhibits the motility of H. pylori (IC50 = 0.25 µg/ml).{62902} Rabeprazole sulfide is cytotoxic to HepG2 liver and PANC-1 pancreatic cancer cells (IC50s = 0.08 and 0.17 µM, respectively).{62900} It is also a potential impurity in commercial preparations of rabeprazole and an acid and neutral hydrolytic degradation product of rabeprazole.{65109,62900}