Product Type: Inhibitor
CAS No.: 12772-57-5
MolecularFormula: C18H17CIO6
Molecular Weight: 364,8
Source: Produced by fermentation
Purity: 97% by TLC
Solubility: Soluble in DMSO
Appearance: White to Yellow Solid
PubChem CID: 6323491
Scientific Background: Radicicol inhibits src (IC50=0.27µM) and src-like kinases(1), leading to hypophosphorylation of retinoblastoma tumor suppressor protein(2). It causes morphological reversion of ras-transformed cells(3) and leads to selective depletion of Raf kinase(4). It also displays anti-angiogenic activity(5), and binds to and inhibits Hsp 90 molecular chaperone(6). It binds more strongly to Hsp90 than to GRP94. It also binds to yeast HSP90, E. coli HtpG and TRAP-1. Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.
References: 1. Kwon H.J., et al. (1992) Cancer Res. 52: 6929.2. Yen A., et al. (1994) Exp.Cell Res. 214: 163.3. Kwon H.J., et al. (1995) J.Biochem.(Tokyo) 118: 221.4. Soga S., et al. (1998) J.Biol.Chem. 273: 822.5. Oikawa T., et al. (1993) Eur.J.Pharmacol. 241: 221.6. Roe S.M. et al. (1999) J.Med.Chem. 42: 260.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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