Product Type: Inhibitor
CAS No.: 53123-88-9
MolecularFormula: C51H79NO13
Molecular Weight: 914,18
Source: Synthetic
Purity: >98%
Solubility: Soluble to 100 mM in ethanol, and to 50 mM in DMSO
Appearance: White Solid
PubChem CID: 5284616
Scientific Background: Rapamycin or Sirolimus is an immunosuppressant and antifungal. It inhibits the response to interleukin-2, and therefore blocks activation of T and B cells. It binds FKBP12 which then inhibits the mTOR pathway (1). There is also potential treatment for Alzheimer;s, autism and HIV infection (2-3).
References: 1. Gruppuso P.A., Boylan J.M., and Sanders J.A. (2011) Cell Cycle. 10(7): EPub.2. Ehninger D., et al. (2008) Nat. Med. 14(8): 843-848.3. Donia M., McCubrey J.A., Bendtzen K., and Nicoletti F. (2010) Br J Clin Pharmacol. 70(6): 784-793.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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