Conjugation: FITC: Fluorescein Isothiocyanate
Description of Target: RAPGEF1 is a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade protein may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation.This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human RAPGEF1
Key Reference: Niclas,J., (2007) Exp. Cell Res. 313 (18), 3881-3891
Molecular Weight: 120kDa
Peptide Sequence: Synthetic peptide located within the following region:
LWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKProduct Format: Liquid. Purified antibody supplied in 1x PBS buffer.
Protein Name: Rap guanine nucleotide exchange factor 1
Protein Size: 1077
Purification: Affinity Purified
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