Clone: A5
Background: Basement membrane components play an important role in cell adhesion, locomotion, differentiation and embryonic compartmentalization. Laminin anchors cells to the basement membrane through interactions with integrins at the cell surface and collagens in the basement membrane.
Source: A5 is a rat monoclonal IgG2a antibody derived by fusion of mouse myeloma cells with spleen cells from a Fisher rat immunized with a laminin preparation from the EHS mouse tumor.
Specificity: A5 reacts with laminin. In the reference of Ljubimova et al [2] its reactivity is further specified to laminin gamma1.
References: 1. Ljubimov, A. V., Bartek, J., Couchman, J. R., Kapuller, L. L., Veselov, V. V., Kovarik, J., Perevoshchikov, A. G., and Krutovskikh, V. A. (1992). Distribution of individual components of basement membrane in Human colon polyps and adenocarcinomas as revealed by monoclonal antibodies. Int J Cancer 50, 562-66. 2. Ljubimova, J.Y., Lakhter, A.J., Loksh, A., Yong, W.H., Riedinger, M.S., Miner, J.H., Sorokin, L.M., Ljubimov, A.V., Black, K.L. (2001). Overexpression of alpha4, chain-containing laminins in Human glial tumors identified by gene microarray analysis. Cancer Research 61, 5601-10.
UniProt: P11047
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This product contains sodium azide. To prevent formation of toxic vapors, do not mix with strong acidic solutions. To prevent formation of potentially explosive metallic azides in metal plumbing, always wash into drain with copious quantities of water.This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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