Rat anti-Mouse IL-6, clone MP5-20F3 (Monoclonal)

Clone Number: MP5-20F3

Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers

Concentration: 100 ug/ml

Storage buffer: PBS with 0.1% BSA and 0.02% sodium azide

Additional info: The antibody neutralizes mouse interleukin 6 (IL-6). It does not cross-react with LPS (the component of the bacterial cell wall which is considered responsible for the toxicity of gram-negative bacteria) and TNFalpha nor does it bind to either human or rat IL-6. The antibody inhibits IL-6 induced proliferation of the B9 assay. IL-6 is a pluripotent 20-22 kDa cytokine which plays a role in the pathophysiology of severe infection and regulates the immune response, acute phase reaction and haematopoiesis. IL-6 plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. Continuous IL-6 gene expression makes an essential contribution to a multistep oncogenesis of plasma cell neoplasia. IL-6 is a very useful culture supplement for the generation of a high number of antibody-producing hybridomas.

References: Takatsuki et al. J Immunol 1988;141:3072/McKenzie et al. J Immunol 1988;141:2907/van Snick et al. Annu Rev Immunol 1990;8:253

• SKU: SANMON5073
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MON5073
• Green Labware: No
• Package Unit: 1 ml
• Quantity Unit: STK
• Reactivity: Mouse (Murine)
• Clonality: Monoclonal
• Application: Immunoprecipitation, ELISA, Functional Assay
• Isotype: IgG1
• Host: Rat