Clone Number: ER-TR9
Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers
Concentration: 200 ug/ ml
Storage buffer: Sterile cell culture medium with 0.02% sodium azide
Additional info: The monoclonal antibody ER-TR9 recognizes murine SIGN-related 1 (SIGN-R1). Mouse SIGN-R1,- a homolog of human DC-SIGN, is a 37 kDa type II transmembrane protein containing a single, C-terminal C-type lectin domain. SIGN-R1 is a specific marker for the identification of macrophage subpopulations present in the marginal zone of spleen (the so-called marginal zone macrophages (MZM)), in the lymph node medulla, and in the peritoneal cavity of some mouse strains. ER-TR9 does not react with macrophages in other regions of the spleen, such as CD169+ marginal metallophils and F4/80+ red pulp macrophages. In the spleen, the MZM function in trapping and clearance of blood-borne microbial antigens. SIGN-R1 mediates the uptake of encapsulated microbes , particularly through the recognition of microbial polysaccharides. Uptake of FITC-labeled dextran by macrophages can be blocked both in vivo and in vitro by the monoclonal antibody ER-TR9. Therefore, the monoclonal antibody ER-TR9 can be used to study the uptake of polysaccharides by macrophages.
References: Dijkstra; C; et al. Immunology 1985; 55: 23/Kretschmer, K, et al J Immunol 2003, 171: 6495/Kang; Y et al. PNAS 2004; 101: 215
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