Clone Name: RB1/2313R
Application Note: IHC-P: 1-2 μg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 106
Specificity/Sensitivity: Its epitope is localized between aa 703-772. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein.
Form: Liquid
Buffer (with preservative): 10mM PBS, 0.05% BSA, 0.05% Sodium azide.
Concentration: 200 μg/ml (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
Uniprot ID: P06400
Antigen Species: Human
Immunogen: Recombinant human full-length Rb1 protein
Purification: Protein A/G purified
Conjugation: Unconjugated
Full Name: RB transcriptional corepressor 1
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