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Encompassing Amino Acids: 2-538 (end)
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Background: RbBP5 binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. In embryonic stem (ES) cells, RbBP5 plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3Lys4 methylation at key developmental loci, including that mediated by retinoic acid. As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at Lys4 of histone H3.
Description: Human retinoblastoma binding protein 5 (RbBP5), GenBank Accession No. NM_005057, a.a. 2 - 538 (end) with N-terminal His-tag, MW= 60 kDa, expressed in an E. coli expression system.
Format: Aqueous buffer solution
Formulation: 20 mM Tris-HCl, pH 7.4, 300 mM NaCl, 10% glycerol, 1 mM TCEP, and 1 µM ZnCl2
Genbank: NM_005057
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal His-tag
Uniprot: Q15291
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Cao, F., et al., PLoS One. 2012 Nov 23; 5(11): e14102.
2. Odho, Z., et al., J Biol Chem. 2010 Oct 22; 285(43): 32967-76.
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